1-Tert-butyl-3-ethylcarbodiimide | CAS 1433-27-8

Efficient Dehydrating Agent for Pharmaceutical and Peptide Synthesis

Product Description

1-Tert-butyl-3-ethylcarbodiimide (CAS 1433-27-8) is a widely used carbodiimide-based coupling agent, valued for its role in facilitating peptide bond formation and other dehydration reactions in organic synthesis. Its balanced steric hindrance and reactivity make it a practical alternative to other carbodiimides like DCC and EDC, especially in moisture-sensitive or scale-up processes.

At Chemlyte Solutions, we offer high-purity 1-Tert-butyl-3-ethylcarbodiimide sourced from reliable manufacturing partners in China. Our product is ideal for use in pharmaceutical research, fine chemical production, and custom synthesis projects where quality, consistency, and efficient reactivity are essential.

Technical Specifications

• Chemical Name: 1-Tert-butyl-3-ethylcarbodiimide

• Synonyms: N-Ethyl-N′-tert-butylcarbodiimide

• CAS No.: 1433-27-8

• Molecular Formula: C7H14N2

• Molecular Weight: 126.20 g/mol

• Purity: ≥98% (GC/HPLC)

• Appearance: Colorless to pale yellow liquid

• Solubility: Miscible with most organic solvents

• Storage: Store in a tightly sealed container in a dry, cool, well-ventilated place; avoid exposure to moisture

Applications of 1-Tert-butyl-3-ethylcarbodiimide

1-Tert-butyl-3-ethylcarbodiimide is a highly effective reagent in modern organic synthesis. Its specific chemical profile lends itself to various industrial and research applications, such as:

1. Peptide Synthesis

• Acts as a mild and efficient coupling agent for peptide bond formation

• Preferred in solid-phase peptide synthesis (SPPS) due to lower byproduct formation

• Compatible with base-sensitive substrates

2. Pharmaceutical Research & Development

• Used in the synthesis of bioactive molecules and advanced pharmaceutical intermediates

• Plays a role in combinatorial chemistry workflows for drug discovery

• Supports SAR studies and analog development

3. Dehydration Reactions & Esterification

• Promotes formation of amides, esters, and other condensation products

• Used in moisture-sensitive conditions due to its low hydrolytic reactivity

• Ideal for laboratory and pilot-scale use in fine chemical manufacturing

4. Custom Synthesis and CDMO Projects

• Frequently requested by CROs and CDMOs for custom molecule production

• Suitable for early-phase synthesis and process optimization

• Available in scalable quantities from grams to kilograms

Packaging & Logistics

• Standard packaging: 1 kg / 5 kg / 25 kg

• Custom packaging: Available on request

• Export-ready documentation: COA, MSDS, TDS, and shipping support for global delivery

Why Choose Chemlyte Solutions?

• Trusted supplier of specialty reagents and intermediates in China

• Proven experience serving global clients in pharma, biotech, and custom synthesis

• Flexible solutions for scale-up, sourcing, and technical support

• ISO-aligned quality control and compliance processes